High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

Codice: E-AB-15716_120μL | Marca: Elabscience | Confezionamento: 120μL

Specie: Human;Mouse;RatIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-15716_120μL
Marca: Elabscience
Specie target: Human;Mouse;Rat
Host: Rabbit
Concentrazione: 0.3 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: WB;IHC
Diluizione: WB 1:500-1:2000;IHC 1:50-1:200
Simbolo target: HMGB1
Ig target: Amphoterin;Chromosomal protein;nonhistone;HMG1;DKFZp686A04236;High mobility group 1;High mobility group box 1;High mobility group protein 1;High mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG-1;HMG1;HMG3;HMGB 1;HMGB1;HMGB1;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein
Area di ricerca: Cancer;Epigenetics and Nuclear Signaling

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