RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene. Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.

Dettagli prodotto

• Codice: E-AB-15724_60μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.6 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:500-1:2000;IHC 1:50-1:200
• Simbolo target: PPP1R13L
• Ig target: IASPP;inhibitor of apoptosis stimulating protein of p53;Inhibitor of ASPP protein;NFkB interacting protein 1;NKIP1;PPP1R13B-like protein;PPP1R13L;Protein iASPP;protein phosphatase 1 regulatory (inhibitor) subunit 13 like;RAI;RelA-associated inhibitor
• Area di ricerca: Cancer;Cell Biology;Epigenetics and Nuclear Signaling