Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Dettagli prodotto

• Codice: E-AB-15735_60μL
• Marca: Elabscience
• Specie target: Human ;Mouse ;Rat
• Host: Rabbit
• Concentrazione: 0.4 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:500-1:2000;IHC 1:25-1:100
• Simbolo target: JNK2
• Ig target: c Jun kinase 2;C Jun N terminal kinase 2;c-Jun N-terminal kinase 2;JNK 55;JNK-55;JNK2 alpha;JNK2;JNK2 beta;JNK2A;JNK2alpha;JNK2B;JNK2BETA;Jun kinase;MAP kinase 9;MAPK 9;Mapk9;Mitogen activated protein kinase 9;Mitogen-activated protein kinase 9;MK09;P54a;p54aSAPK;PRKM9;Protein kinase;mitogen-activated;9;SAPK alpha;SAPK;SAPK1a;Stress activated protein kinase 1a;Stress-activated protein kinase JNK2
• Area di ricerca: Cancer;Cell Biology;Metabolism;Immunology;Signal Transduction