This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Dettagli prodotto

• Codice: E-AB-15932_60μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.7 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: DCC
• Ig target: Colorectal cancer related chromosome sequence 18;Colorectal cancer suppressor;CRC 18;CRC18;CRCR 1;CRCR1;DCC;DCC;Deleted in colorectal cancer protein;Deleted in colorectal carcinoma;Immunoglobulin superfamily DCC subclass member 1;Netrin receptor DCC;Tumor suppressor protein DCC
• Area di ricerca: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Neuroscience