Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Dettagli prodotto

• Codice: E-AB-18676_200μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 1.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:500-1:2000;IHC 1:40-1:200
• Simbolo target: UBXN1
• Ig target: 2B28;4930455J02Rik;D19Ertd721e;MGC124706;MGC6696;mY33K;Protein 2B28;RGD1309471;SAKS1;SAPK substrate protein 1;T25529;UBA/UBX 33.3 kDa protein;UBX domain containing protein 1;UBX domain protein 1;UBXD10;UBXN1
• Area di ricerca: Cell Biology;Signal transduction