HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Dettagli prodotto

• Codice: E-AB-18997_60μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.9 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:300
• Simbolo target: HLA-E
• Ig target: HLA class I histocompatibility antigen E alpha chain;EA1.2;EA2.1;HLA 6.2;HLA class I histocompatibility antigen alpha chain E;HLA class I histocompatibility antigen E alpha chain precursor ;HLA class I histocompatibility antigen E alpha chain precursor;HLA6.2;HLAE;Lymphocyte antigen;Major histocompatibility complex class I E;MHC;MHC class I antigen E;MHC HLA E alpha 1;MHC HLA E alpha 2.1;QA1
• Area di ricerca: Cancer;Immunology