This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.

Dettagli prodotto

• Codice: E-AB-19099_20μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 1.02 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:500-1:2000;IHC 1:50-1:300
• Simbolo target: PCBD1
• Ig target: 4 alpha hydroxy tetrahydropterin dehydratase;4-alpha-hydroxy-tetrahydropterin dehydratase;6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha;DCoH;Dimerization cofactor of hepatic nuclear factor 1 alpha;Dimerization cofactor of hepatocyte nuclear factor 1 alpha;Dimerization cofactor of hepatocyte nuclear factor 1-alpha;Dimerization cofactor of HNF1;Dimerizing cofactor for HNF1;PCBD 1;PCBD;PCBD1;PCD;Phenylalanine hydroxylase stimulating protein;Phenylalanine hydroxylase-stimulating protein;PHS;PHS;Pterin 4 alpha carbinolamine dehydratase;Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha;Pterin carbinolamine dehydratase;Pterin-4-alpha-carbinolamine dehydratase
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Metabolism;Signal transduction