Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Dettagli prodotto

• Codice: E-AB-19212_60μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1.02 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: RITA1
• Ig target: C12orf52 ;Chromosome 12 open reading frame 52 ;RBPJ interacting and tubulin associated 1;RBPJ interacting and tubulin associated protein 1;RBPJ-interacting and tubulin-associated protein;RITA;RITA
• Area di ricerca: Developmental biology;Neuroscience;Signal transduction;Stem cells