Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Dettagli prodotto

• Codice: E-AB-19326_60μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.6 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:300
• Simbolo target: HIPK3
• Ig target: Androgen receptor interacting nuclear protein kinase;Androgen receptor-interacting nuclear protein kinase;ANPK;DYRK6;Fas interacting serine/threonine protein kinase;Fas-interacting serine/threonine-protein kinase;FIST;FIST3;Hipk3;HIPK3;homeodomain interacting protein kinase 3;Homeodomain-interacting protein kinase 3;Homolog of protein kinase YAK1;PKY;RP24 297H17.5;YAK1
• Area di ricerca: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal transduction