Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Codice: E-AB-20911_120μL | Marca: Elabscience | Confezionamento: 120μL

Specie: Human;Mouse;Rat;MonkeyIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-20911_120μL
Marca: Elabscience
Specie target: Human;Mouse;Rat;Monkey
Host: Rabbit
Concentrazione: 1 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: WB;IHC-p;IF
Diluizione: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000
Simbolo target: IκB-α (phospho Ser32/36)
Ig target: I kappa B alpha;I-kappa-B-alpha;IkappaBalpha;IkB-alpha;IKBA;IKBA;IKBalpha;MAD 3;MAD3;Major histocompatibility complex enhancer-binding protein MAD3;NF kappa B inhibitor alpha;NF-kappa-B inhibitor alpha;NFKBI;NFKBIA;Nuclear factor of kappa light chain gene enhancer in B cells;Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Immunology;Signal Transduction

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