Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Dettagli prodotto

• Codice: E-AB-22044_200μL
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Monoclonal
• Clone: Clone:8K2
• Coniugazione: Unconjugated
• Applicazione: WB;IHC-p;IF;IP
• Diluizione: WB 1:500-1:2000;IHC 1:50-300;IF 1:50-1:200;IP 1:100-1:300
• Simbolo target: XRCC4
• Ig target: DNA double strand break repair and V(D)J recombination protein XRCC4;DNA repair protein XRCC4;SSMED;X ray repair complementing defective repair in Chinese hamster cells 4;X ray repair cross complementing 4;X ray repair cross complementing protein 4;X-ray repair cross-complementing protein 4;XRCC 4;XRCC4;XRCC4
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling