Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.

Dettagli prodotto

• Codice: E-AB-32916_120μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC-p
• Diluizione: WB 1:500-1:2000;IHC 1:100-1:300
• Simbolo target: Smad2
• Ig target: Drosophila;homolog of;MADR2;hMAD-2;HsMAD2;JV18;JV18-1;JV181;MAD;MAD homolog 2;MAD Related Protein 2;Mad-related protein 2;MADH2;MADR2;MGC22139;MGC34440;Mother against DPP homolog 2;Mothers against decapentaplegic homolog 2;Mothers against decapentaplegic;Drosophila;homolog of;2;Mothers against DPP homolog 2;OTTHUMP00000163489;Sma and Mad related protein 2;Sma- and Mad-related protein 2 MAD;SMAD 2;SMAD family member 2;SMAD;mothers against DPP homolog 2;SMAD2;SMAD2
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Signal Transduction;Stem Cells