This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Ig target: DAP1;GAP modifying protein 1;GAP-modifying protein 1;GMP 1;GMP1;OFC10;PIC 1;PIC1;SENP2;Sentrin 1;Sentrin;Small ubiquitin related modifier 1;Small ubiquitin-like modifier 1;Small ubiquitin-related modifier 1;SMT3;SMT3 homolog 3;SMT3 suppressor of mif two 3 homolog 1;SMT3;yeast;homolog 3;Smt3C;SMT3H3;SUMO-1;SUMO1;SUMO1;Ubiquitin homology domain protein PIC1;Ubiquitin Like 1;Ubiquitin like protein SMT3C;Ubiquitin like protein UBL1;Ubiquitin-homology domain protein PIC1;Ubiquitin-like protein SMT3C;Ubiquitin-like protein UBL1;UBL 1;UBL1
Area di ricerca:Cancer;Cell Biology;Cardiovascular;Metabolism
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