IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

Dettagli prodotto

• Codice: E-AB-52202_200μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.96 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: PTPRN
• Ig target: CA 512;FLJ16131;IA 2;IA 2/PTP;IA2;IA2/PTP;ICA 3;ICA 512;ICA3;ICA512;Islet cell antigen 2;Islet cell antigen 512;Islet cell autoantigen 3;Protein tyrosine phosphatase like N;Protein tyrosine phosphatase like N precursor;Protein tyrosine phosphatase receptor type N;PTP IA 2;PTP IA-2;PTP IA2;PTPIA 2;PTPN;Ptprn;PTPRN protein;PTPRN;R PTP N;R-PTP-N;Receptor type tyrosine protein phosphatase like N;Receptor-type tyrosine-protein phosphatase-like N;RPTPN
• Area di ricerca: Cancer;Metabolism;Neuroscience;Signal Transduction