Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: WB;IHC
Diluizione: WB 1:500-1:2000;IHC 1:25-1:100
Simbolo target: ATXN7L3
Ig target: AT7L3;Ataxin 7 like 3;Ataxin 7 like protein 3;Ataxin-7-like protein 3;atxn7l3;SAGA associated factor 11 homolog;SAGA-associated factor 11 homolog
Area di ricerca:Cell Biology;Epigenetics and Nuclear Signaling
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