The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Dettagli prodotto

• Codice: E-AB-53352_200μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.66 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:30-1:150
• Simbolo target: XPC
• Ig target: DNA repair protein complementing XP C cells;DNA repair protein complementing XP-C cells;DNA repair protein complementing XPC cells ;p125;RAD4;Xeroderma pigmentosum complementation group C;Xeroderma pigmentosum group C complementing protein;Xeroderma pigmentosum group C protein;Xeroderma pigmentosum group C-complementing protein;Xeroderma pigmentosum group III;XP 3;XP C;XP group C;XP3;Xpc;XPC gene;XPC;XPCC
• Area di ricerca: Epigenetics and Nuclear Signaling