This protein mediates pre-mRNA alternative splicing regulation. It binds to splice sites in pre-mRNA and regulates splice site selection and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It can regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro).

Codice: E-AB-53542_20μL | Marca: Elabscience | Confezionamento: 20μL

Specie: Human;Mouse;RatIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-53542_20μL
Marca: Elabscience
Specie target: Human;Mouse;Rat
Host: Rabbit
Concentrazione: 0.6 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: IHC
Diluizione: IHC 1:30-1:150
Simbolo target: YBX1
Ig target: BP 8;CBF-A;CCAAT binding transcription factor I subunit A;CCAAT-binding transcription factor I subunit A;CSDA2;CSDB;DBPB;DNA binding protein B;DNA-binding protein B;EFI-A;Enhancer factor I subunit A;MDR NF1;MGC104858;MGC110976;MGC117250;NSEP 1;NSEP1;Nuclease sensitive element binding protein 1;Nuclease-sensitive element-binding protein 1;p50;Q15905;Y-box binding protein 1;Y-box transcription factor;Y-box-binding protein 1;YB 1;YB-1;YBOX1;YBX 1;ybx1
Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Developmental Biology;Stem Cells;Tags and Cell Markers

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