NR1H3,also known as LXRA,is a liver X receptors,which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function,controlling transcriptional programs involved in lipid homeostasis and inflammation.. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor,then participates in regulating expression of target genes containing LXR response elements.
