CD2 is mainly expressed on the surface of mature T cells and NK cells, while B cells usually do not express CD2. It can be used for the identity and research of normal T cells and related tumors. CD2 plays an important role in the differentiation of precursor and mature T cell lymphoma.
CD30, a member of the tumor necrosis factor receptor superfamily, is a positive regulator of apoptosis. CD30 is expressed on activated B and T lymphocytes, Hodgkin's lymphoma R-S cells, plasma cells, NK cells, monocytes, and large lymphocytes. CD30 was expressed in classical Hodgkin's disease, anaplastic large cell lymphoma and anaplastic diffuse large B-cell lymphoma. CD30 was also expressed in primary cutaneous CD30-positive lymphoproliferative disease and some mycosis fungoides. CD30 can also be used to distinguish germ cell tumors, which are positive for embryonal carcinoma but negative for seminoma.
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