CD31 is mainly expressed in endothelial cells, platelets, monocyte macrophages, granulocytes and B lymphocytes. Its sensitivity and specificity are higher than those of CD34 and VIII in the judging and differential judging of benign and malignant angiogenic tumors.
CD34 is a single strand membrane penetrating protein with a molecular weight of 105~120 kDa, which is expressed in early LYMPHOPOIETIC stem cells, Progenitor cells, vascular endothelial cells, embryonic fibroblasts and some nerve tissue cells. It is mainly used for the differentiation of benign and malignant angiogenic tumors. CD34 and CD117 are used in the identity gastrointestinal stromal tumors. CD34 is positive in 80%~ 102% of dermatofibrosarcoma protuberans, which could be differentiated from dermatofibroma.
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