The CD3 protein is a complex of five non-covalently linked peptide chains and is expressed on the surface of all T cells. CD3 is a specific T cell antibody. B cells, myeloid cells, macrophages and any other cells did not express CD3 except Purkinje cells in the cerebellum. The antibody recognizes both neoplastic and nonneoplastic T lymphocytes and NK cells. Some mycosis fungoides, pleomorphic lymphoma, and anaplastic large cell lymphoma can be negative for CD3. Nk-cell lymphoma can present as a cytoplasmic reaction.
CD43 is expressed in normal T lymphocytes, myelocytes and histiocytes, and in extramedullary myeloma / granulosarcoma. Most of T-cell lymphoma, low-differentiated B-cell lymphoma (30%), most of acute T-lymphocytic leukemia and some of acute B-lymphocytic leukemia can be labeled with CD43 antibodies.
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