CD44 is a member of cell adhesion molecule family (CAMs) that mediates cell and extracellular matrix. It is expressed on the cell surface and interacts with cytoskeleton protein. It is mainly expressed on the surface of myoepithelial basement membrane of some acini and ducts. CD44 (HCAM), which is widely expressed in hematopoietic cells and mesodermal cells, is a marker of these cells.
CD45 (Leukocyte Common Antigen) is a protein family composed of five or more high molecular weight glycoproteins, mainly expressed on the surface of leukocytes, including T, B lymphocytes, polymorphonuclear leukocytes, monocytes, etc., but not expressed in erythrocytes, platelets and non hematopoietic systems. It is a specific marker to distinguish lymphoma leukaemia from non hematopoietic tissue tumors (such as undifferentiated small cell carcinoma and small round cell sarcoma).
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