CD4 is a glycoprotein, belongs to the immunoglobulin superfamily related to HLA class II antigen recognition. In lymphoid tissue, there are a large number of CD4 + T cells in the perifollicular area, and a small number of CD4 + T cells in the germinal center and mantle. CD4 is also expressed in sinusoidal cells, monocytes and monocyte derived cells. CD4 plays an important role in the classification of lymphocytes and malignant lymphoma.
CD56 is a membrane glycoprotein that plays an important role in embryonic development and neural cell interaction. CD56 is widely found in neurons, glial cells, skeletal muscle cells, most types of neuroendocrine cells, and various epithelial cells. In the hematopoietic system, CD56 is a prototypical marker of NK cells and is also present in CD4+ and CD8+ T cell subsets. It is mainly used in the diagnosis and research of neuroectodermal tumors, small cell lung cancer and NK cell lymphoma.
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