This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
A synthesized peptide derived from human AKR1C2, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human AKR1C3, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human AKR1C4, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human AKR1CL2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human AKR1D1.
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
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