The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
A synthesized peptide derived from human AMPKgamma2, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from Human AMPS.
Calcium-binding enzyme that initiates starch digestion in the oral cavity.Catalyzes the hydrolysis of internal(1->4)-alpha-D-glucosidic bonds,yielding a mixture of maltose,isomaltose,small amounts of glucose as well as small linear and branched oligosaccharides called dextrins.
A synthesized peptide derived from human AMY2A.
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.
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