ANKMY2 (ankyrin repeat and MYND domain containing 2) is a 441 amino acid protein that contains three ANK repeats and one MYND-type zinc finger. Encoded by a gene that maps to human chromosome 7p21.1, ANKMY2 is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans. Downregulation of ANKMY2, associated with frequent deletions of human chromosome 7p22.1, indicate that ANKMY2 may role a role in the pathogenesis of natural killer (NK)-cell malignancies. ANKMY2 is also upregulated by enforced expression of Hox11, which functions broadly to hinder hemopoiesis, diverts differentiation to an alternative fate and promotes pre-leukaemic states.
This protein may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery. ANKRA2 is a megalin- and BKCa potassium channel-interacting factor. It is a protein known to interact with HDAC4 and HDAC5.ANKRA2 is important for transcriptional repression by AhRR.
A synthesized peptide derived from human ANKRD12.
A synthesized peptide derived from human ANKRD13C.
A synthesized peptide derived from human ANKRD1, corresponding to a region within the internal amino acids.
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
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