The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene.
A synthesized peptide derived from human PWWP2A.
A synthesized peptide derived from human PWWP2B, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PXMP3, corresponding to a region within the internal amino acids.
Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
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