Thetetratricopeptide repeat(TPR) is astructural motif. It consists in a degenerate 34 amino acidsequence motifidentified in a wide variety ofproteins. It is found in tandem arrays of 3–16 motifs,[1]which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These repeats usuallyfoldtogether to produce a single, linearsolenoid domaincalledTPR domain.
A synthesized peptide derived from human TTC30A.
A synthesized peptide derived from human TTC37.
TTC38 (tetratricopeptide repeat domain 38) is a 469 amino acid protein that contains three TPR repeats and belongs to the TTC38 family. The gene that encodes TTC38 consists of over 26,000 bases and maps to 22q13. Housing over 500 genes, chromosome 22 is the second smallest chromosome in the human genome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. In addition, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Inserisci la tua e-mail e seleziona le aree di interesse per ricevere le ultime novità, approfondimenti e promozioni.
Seleziona uno o più ambiti di interesse per ricevere comunicazioni più utili e mirate.
2025 TEMA Ricerca - All Rights Reserved.
