A synthesized peptide derived from human UBE2D1, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human UBE2D2, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human UBE2D3, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human UBE2E1.
A synthesized peptide derived from human UBE2E2, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human UBE2E3, corresponding to a region within N-terminal amino acids.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
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