This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
A synthesized peptide derived from human USP17L, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human USP18, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human USP19, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human USP1, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human USP21.
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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