Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
A synthesized peptide derived from human WNK1, corresponding to a region within N-terminal amino acids.
A synthetic peptide from human WNK1
A synthesized peptide derived from human WNK2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human WNK3, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human WNK4.
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
A synthesized peptide derived from human Wnt10a, corresponding to a region within N-terminal amino acids.
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