This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined.
A synthesized peptide derived from human ZNF398.
A synthesized peptide derived from human ZNF410.
ZNF410 is the transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
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