This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
A synthesized peptide derived from human UNC13D, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human UNC45B.
A synthesized peptide derived from human UNC5B, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human UNC5C, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human UNC80.
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