TheZBTB6protein contains a conserved N-terminal domain known as the POZ domain that inhibits DNA binding. Sequence analysis predicted that the 424-amino acid protein contains 4 C-terminal zinc finger motifs and an N-terminal domain of 120 amino acids found in many different zinc finger proteins and a group of non-zinc finger poxvirus proteins.
LRF, formerly identified as Pokemon, is a poxvirus zinc finger (POZ) domain-containing transcription factor that influences cell differentiation. LRF (for leukemia/lymphoma related factor) is also known as zinc finger and BTB domain containing 7A, ZBTB7, TIP21, FBI1 and FBI-1. POZ-domain transcription factors contain a POZ or BTB type protein-protein interaction domain at their N-terminus and Kruppel-type zinc fingers at their C-terminus. LRF is inducible during both murine and human preadipocyte differentiation and may contrib-ute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation.
A synthesized peptide derived from human ZBTB7B.
A synthesized peptide derived from human ZBTB7C.
May be involved in transcriptional regulation.
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