The zinc finger CCCH domain-containing protein 7A (ZC3H7A), also known as ZC3H7, HSPC055 or ZC3HDC7, is a 971 amino acid protein that contains a C3H1-type zinc finger domain, three C3H1-type zinc fingers and three TPR repeats. Belonging to the ZC3H12 family, ZC3H7A localizes to the nucleus. Existing as two alternatively spliced isoforms, ZC3H7A is encoded by a gene located on human chromosome 16p13.13. Chromosome 16 makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.
A synthesized peptide derived from human ZC3H7B, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human ZC3H8, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human ZC3HAV1, corresponding to a region within the internal amino acids.
he zinc-finger antiviral protein (ZAP) was originally identifed from a rat cDNA library due to its conferring resistance to retroviruses. ZC3HAV1 is a CCCH-type zinc finger protein,it may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants,each encoding distinct isoforms.
A synthesized peptide derived from human ZC4H2.
A synthesized peptide derived from human ZCCHC10.
A synthesized peptide derived from human ZCCHC11, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human ZCCHC17, corresponding to a region within the internal amino acids.
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