ZNF8 (zinc finger protein 8) is a 575 amino acid protein that belongs to the Krüppel C2H2-type zinc-finger protein family and contains seven C2H2-type zinc fingers and a KRAB domain. Localizing to the nucleus and ubiquitously expressed, ZNF8 is thought to play a role in transcriptional regulation and is encoded by a gene that maps to human chromosome 19q13.43.
A synthesized peptide derived from human ZNHIT1, corresponding to a region within the internal amino acids.
ZNHIT1, Zinc finger HIT domain containing protein 1, appears to play a role in p53-mediated apoptosis induction.
ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
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